Covid-19 application

A software like the Pulse Physiology engine is very useful during a pandemic. It allows us to predict events.

During the coronavirus pandemic, Pulse was used to predict if two Covid-19 patients could share a ventilator. And if that is the case, which two patients are more likely to share one.

1. Modelisation of a Covid patient

Studies have confirmed COVID-19 pneumonia patients fulfill the criteria of Acute Respiratory Distress Syndrome (ARDS). Consequently, the existing Pulse ARDS pathophysiology model was used to model Covid-19.

Here, we compare three Covid-19 patients. The first one with a mild severity ARDS (ARDS 0.3), the second one with a moderate one (ARDS 0.6), and the last one with severe ARDS (ARDS 0.9).

heartrate
ArterialPressure
ArterialPressure debut
Systol
Diastol
Map
EndTidalCarbonDioxide
RR
lungvolume
TotalLungVolume debut
SkinTemperature
inspiratory
Inspiratory debut
expiratory
Expiratory debut

We can notice an increase in the respiration rate, which is the expected result.

More over, we also notice an increase in the skin temperature, which is also an expected result.

2. Particles

In July 2020, Michael Riediker and Dai-Hua Tsai published an article on the "Estimation of Viral Aerosol Emissions From Simulated Individuals With Asymptomatic to Moderate Coronavirus Disease 2019".

In the article, we can find the viral load of coronavirus used to simulate Covid-19 patients, according to the number of viral copies present in sputum and swab samples of individuals with COVID-19.

Table 1. Viral load (copies/mL)

Low emitter

Typical emitter

High emitter

1000

106

1.3*1011

We can correlate these numbers with the expiratory flow results and have an approximation of the viral load for each individual.

References